Membrane currents underlying delayed rectification and pace-maker activity in frog atrial muscle
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چکیده
منابع مشابه
Delayed Rectification and Anomalous Rectification in Frog's Skeletal Muscle Membrane
Delayed rectification was elicited in frog's skeletal muscles bathed in choline-Ringer's solution, in normal Ringer's solution with tetrodotoxin, in 40 mM Na(2)SO(4) solution with tetrodotoxin, and even in 40 mM K(2)SO(4) solution when the membrane had been previously hyperpolarized. However, after a sustained depolarization current-voltage relations in 40 mM K(2)SO(4) and in 40 mM Na(2)SO(4) s...
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The double sucrose-gap voltage-clamp technique was applied to frog atrial tissue to investigate the ionic currents responsible for the action potential in this tissue. Membrane depolarization elicited two distinct components of inward current when the test node was exposed to normal Ringer solution: a fast inward current and a slow inward current. The fast inward current appeared to be carried ...
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Tetanic stimulation of skeletal muscle fibers elicits a train of spikes followed by a long-lasting depolarization called the late after-potential (LAP). We have conducted experiments to determine the origin of the LAP. Isolated single muscle fibers were treated with a high potassium solution (5 mM or 10 mM K) followed by a sudden reduction of potassium concentration to 2.5 mM. This procedure pr...
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Changes in membrane current in response to an elevation of [Na]i were studied in enzymatically dispersed frog atrial cells. Na loading by either intracellular dialysis or exposure to the Na ionophore monensin produces changes in membrane current that resemble the "creep currents" originally observed in cardiac Purkinje fibers during exposure to low-K solutions. Na loading induces a transient ou...
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The effect of sulhydryl reagents on nonlinear membrane currents of frog skeletal muscle fibers has been studied using the triple Vaseline gap voltage-clamp technique. These compounds, which are known to interfere with depolarization contraction coupling, also appear to diminish intramembranous charge movement recorded with fibers polarized to -100 mV (charge 1). This effect, however, is accompa...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1969
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1969.sp008940